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1. 发明申请

US20170333522A1 EXPRESSION AND FUNCTION OF GPR64/ADGRG2 IN ENDOCRINE SYSTEMS AND METHODS TO TARGET IT THERAPEUTICALLY 审中-公开
公开(公告)号：US20170333522A1
公开(公告)日：2017-11-23
申请号：US15589526
申请日：2017-05-08
申请人： Nariman Balenga , John Olson
发明人： Nariman Balenga , John Olson
IPC分类号： A61K38/17 , A61K45/06 , G01N33/50 , C12Q1/68 , A61K48/00
CPC分类号： A61K38/177 , A61K45/06 , A61K48/00 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/5041 , G01N2333/635 , G01N2333/726 , G01N2800/04
摘要： Provided herein are methods of treating hypercalcemia in a subject, comprising administering to the subject a therapeutically effective amount of a composition that decreases the expression level and/or activity of GPR64. Compositions comprising the therapeutic agents and methods of screening for agonists and inhibitors of GPR64 are also provided. Compositions and methods for treating primary hyperparathyroidism, secondary hyperparathyroidism, hypoparathyroidism, and osteoporosis without hyperparathyroidism are also provided.

2. 发明申请

US20110300994A1 Exercise Device and System 有权
标题翻译：运动装置和系统
公开(公告)号：US20110300994A1
公开(公告)日：2011-12-08
申请号：US13129930
申请日：2009-11-19
申请人： Julian Kyle Verkaaik , Jason Murray Nicholls , Marcus James King , Joseph John Olson
发明人： Julian Kyle Verkaaik , Jason Murray Nicholls , Marcus James King , Joseph John Olson
IPC分类号： A63B71/00
CPC分类号： A61H1/0274 , A61H1/0285 , A61H2001/0203 , A61H2201/1261 , A61H2201/1276 , A61H2201/1638 , A61H2201/1659 , A61H2201/169 , A61H2201/5007 , A61H2201/5061 , A61H2201/5097 , A63B21/00178 , A63B21/012 , A63B21/159 , A63B21/4017 , A63B21/4033 , A63B21/4035 , A63B21/4047 , A63B22/0002 , A63B22/0005 , A63B22/0061 , A63B23/03525 , A63B23/03533 , A63B23/12 , A63B23/1209 , A63B23/1254 , A63B23/14 , A63B24/0003 , A63B2022/0028 , A63B2022/003 , A63B2022/0035 , A63B2022/0053 , A63B2022/0074 , A63B2022/0092 , A63B2022/0094 , A63B2024/0096 , A63B2071/0647 , A63B2071/0652 , A63B2220/05 , A63B2220/13 , A63B2220/51 , A63B2220/58 , A63B2220/806 , A63F13/06 , A63F13/24 , A63F13/65 , G06F3/017 , G06F3/03
摘要： A bilateral upper limb exercise device (10) for exercising a user's arms comprising a central mounting structure (12) that is mountable to a fixed surface or structure (15), left and right limb supports (14a,14b) for supporting the forearm and/or hand of a respective arm of the user, and a pair of articulated linkage arms (22a,22b) that are pivotably coupled to opposite sides of the central mounting structure (12) and which are arranged to support a respective limb support (14a,14b) for movement in at least two degrees of freedom in a two-dimensional (2D) movement plane. A mirroring mechanism is also operatively coupled to the articulated linkage arms (22a,22b) such that movement of the opposing limb support relative to a central line of symmetry of the device.
摘要翻译：一种用于锻炼使用者手臂的双边上肢锻炼装置（10），包括可安装到固定表面或结构（15）的中心安装结构（12），用于支撑前臂的左右肢体支撑件（14a，14b）（22a，22b），其可枢转地联接到中心安装结构（12）的相对侧并且被布置成支撑相应的肢体支撑件（14a，22b），所述连接臂，14b），用于在二维（2D）运动平面中以至少两个自由度运动。镜像机构还可操作地联接到铰接的联动臂（22a，22b），使得相对的肢体支撑件相对于装置的中心对称线的运动。

3. 发明申请

US20070244674A1 Apparatus and method to monitor device status 审中-公开
标题翻译：监控设备状态的设备和方法
公开(公告)号：US20070244674A1
公开(公告)日：2007-10-18
申请号：US11396663
申请日：2006-04-03
申请人： Andrew Hourselt , John Olson
发明人： Andrew Hourselt , John Olson
IPC分类号： G06F17/10
CPC分类号： G05B23/0297
摘要： A method is disclosed to monitor the status of devices disposed in a computing system. The method provides a computing device comprising a plurality of devices, and a system monitoring algorithm comprising a monitoring interval and a device status for each of (N) devices disposed in the computing device, where those (N) devices comprise a portion or all of the plurality of devices. The method sets for each value of (i), the (i)th monitoring interval and the (i)th device status, where the (i)th device status is selected from the group comprising active and inactive; where (i) is greater than or equal to 1 and less than or equal to (N). As long as the (i)th device status is set to active, the method monitors the status of the (i)th device at the expiration of each (i)th monitoring interval. On the other hand, as long as the (i)th device status is set to inactive, the method does not monitoring the status of the (i)th device at the expiration of each (i)th monitoring interval.
摘要翻译：公开了一种监视设置在计算系统中的设备的状态的方法。该方法提供包括多个设备的计算设备，以及系统监视算法，其包括设置在计算设备中的（N）个设备中的每一个的监视间隔和设备状态，其中，（N）个设备包括部分或全部多个设备。该方法为（i），（i）监视间隔和（i）设备状态的每个值设置，其中（i）设备状态从包括活动和非活动的组中选择; 其中（i）大于或等于1且小于或等于（N）。只要（i）设备状态被设置为活动，则该方法在每个第（i）个监视间隔期满时监视第（i）设备的状态。另一方面，只要（i）设备状态被设置为不活动，则在第（i）个监视间隔期满时，该方法不监视第（i）设备的状态。

4. 发明申请

US20070231727A1 Toner formulations containing extra particulate additive 审中-公开
标题翻译：含有额外颗粒添加剂的调色剂配方
公开(公告)号：US20070231727A1
公开(公告)日：2007-10-04
申请号：US11395692
申请日：2006-03-31
申请人： Brian Baird , John Earley , Yueping Fu , Rick Jones , Lale Lovell , George Marshall , John Olson
发明人： Brian Baird , John Earley , Yueping Fu , Rick Jones , Lale Lovell , George Marshall , John Olson
IPC分类号： G03G9/08
CPC分类号： G03G9/0819 , G03G9/08782 , G03G9/09708 , G03G9/09716
摘要： The present invention relates to the use of extra particulate additives in selected chemically processed toner compositions for use in an image forming apparatus. The extra particulate additive may have a controlled aspect ratio and be combined with the chemically processed toner. The chemically processed toner may provide toner particles having controlled diameters and rheological properties that may be combined with a release agent. The release agent may also be selected with respect to, e.g., concentration and/or mean domain size within the toner particles including considerations of coating chemistry and/or DSC melting behavior.
摘要翻译：本发明涉及在选择的化学处理调色剂组合物中用于成像设备中使用额外的颗粒添加剂。额外的颗粒添加剂可以具有受控的纵横比并与化学处理的调色剂组合。化学处理的调色剂可以提供具有可与脱模剂组合的受控直径和流变性质的调色剂颗粒。还可以根据例如调色剂颗粒中的浓度和/或平均域尺寸来选择脱模剂，包括涂料化学和/或DSC熔融行为的考虑。

5. 发明申请

US20070166792A1 Increasing hemoglobin and other heme protein production in bacteria by co-expression of heme transport genes 审中-公开
标题翻译：通过血红素转运基因的共表达增加细菌中血红蛋白和其他血红素蛋白质的产生
公开(公告)号：US20070166792A1
公开(公告)日：2007-07-19
申请号：US11724006
申请日：2007-03-14
申请人： John Olson , Douglas Henderson
发明人： John Olson , Douglas Henderson
IPC分类号： C12P21/06 , C12N1/21 , C07K14/805 , C12N15/74
CPC分类号： C07K14/805
摘要： The present disclosure relates to methods for increasing heme uptake in a Gram-negative bacterium comprising expressing at least one transgenic heme transport gene in the bacterium. The present disclosure also relates to heme protein production cells comprising at least one transgenic heme transport gene and a heme protein gene and plasmids comprising one or more heme transport genes and a promoter operable to promote expression of the genes by iron depletion or by the addition of an inducer molecule. The present disclosure also relates to systems for heme protein production.
摘要翻译：本公开涉及在革兰氏阴性细菌中增加血红素摄取的方法，包括在细菌中表达至少一种转基因血红素转运基因。本公开内容还涉及包含至少一种转基因血红素转运基因和血红素蛋白质基因的血红素蛋白质生产细胞和包含一种或多种血红素转运基因的质粒和可操作以通过铁消耗促进基因表达的启动子或通过添加诱导剂分子。本公开还涉及血红素蛋白质生产的系统。

6. 发明授权

US07210390B1 Buoyancy device for personnel protective plates 有权
标题翻译：用于人员防护板的浮力装置
公开(公告)号：US07210390B1
公开(公告)日：2007-05-01
申请号：US11063835
申请日：2005-02-23
申请人： John Olson , Jeffrey A. Mears , Rob Monks , P. Victor Kelsey
发明人： John Olson , Jeffrey A. Mears , Rob Monks , P. Victor Kelsey
IPC分类号： F41H1/02
CPC分类号： F41H5/04 , F41H1/02 , Y10S428/911
摘要： A personal ballistic protective device having a first layer comprised of ballistic material and a second layer comprised of buoyant material. The second layer preferably has a density sufficient to counteract a density of at least the first layer of ballistic material such that the first layer and the second layer have a combined density substantially equal to or less than the density of water. A method of counteracting negative buoyancy in a personal protective device is also disclosed.
摘要翻译：具有由防弹材料构成的第一层和由浮力材料构成的第二层的个人防弹装置。第二层优选具有足以抵消至少第一层弹道材料的密度的密度，使得第一层和第二层具有基本上等于或小于水的密度的组合密度。还公开了抵消个人保护装置中的负浮力的方法。

7. 发明申请

US20050255401A1 CLOSED AIR CIRCULATION TONER ROUNDING 有权
标题翻译：关闭空气循环调音台
公开(公告)号：US20050255401A1
公开(公告)日：2005-11-17
申请号：US10862871
申请日：2004-06-07
申请人： John Earley , George Marshall , John Olson , Trent Peter , Minerva Piffarerio , Vincent Ting , Ronald Whildin
发明人： John Earley , George Marshall , John Olson , Trent Peter , Minerva Piffarerio , Vincent Ting , Ronald Whildin
IPC分类号： G03G5/00 , G03G9/00 , G03G9/08 , G03G9/087 , G03G9/097
CPC分类号： G03G9/08782 , G03G9/0808 , G03G9/0815 , G03G9/09725
摘要： Toner is rounded by vigorously mixing less than about 5 percent by weight of particulate silica to the total weight of a starting toner in a closed, recirculating air system. The starting toner contains at least about 4.5 percent by weight of the starting toner of a wax and additionally contains at least 5 percent by weight of the starting toner of a softening agent. The temperature during the mixing is no more than 13 degrees C. above the onset of the glass transition temperature of the starting toner. The final toner comprises rounded starting toner having particulate silica embedded during the mixing process.
摘要翻译：通过在密闭的循环空气系统中将少于约5重量％的颗粒二氧化硅剧烈混合到起始调色剂的总重量来使调色剂成圆形。起始调色剂含有至少约4.5重量％的蜡的起始调色剂，另外含有至少5重量％的软化剂的起始调色剂。在起始调色剂的玻璃化转变温度开始之后，混合期间的温度不超过13摄氏度。最终的调色剂包括在混合过程中嵌入了颗粒状二氧化硅的圆形起始调色剂。

8. 发明申请

US20050000838A1 Portable container with vertical hanging folder storage 审中-公开
标题翻译：便携式集装箱，垂直悬挂文件夹存放
公开(公告)号：US20050000838A1
公开(公告)日：2005-01-06
申请号：US10798633
申请日：2004-03-11
申请人： Timothy Killinger , Gilius Gaska , Michael Pyle , John Olson , Justin Guthrie
发明人： Timothy Killinger , Gilius Gaska , Michael Pyle , John Olson , Justin Guthrie
IPC分类号： A45C3/02 , A45C5/14 , A45C13/02 , A47B63/00 , B42F17/00 , B65D85/00
CPC分类号： A47B63/00 , A45C3/02 , A45C5/146 , A45C13/02 , B42F17/00
摘要： A portable container for holding office products and documents includes a rigid structural portion capable of holding hanging folders in a cascading configuration and a cover portion attached to the rigid structural portion. The cover portion may be made from a pliable material, to make the container lightweight and aesthetically pleasing. The container may include a wire insert for supporting hanging file folders.
摘要翻译：用于保持办公用品和文件的便携式容器包括能够保持级联构造的悬挂文件夹的刚性结构部分和附接到刚性结构部分的盖部分。盖部分可以由柔韧材料制成，以使容器重量轻且美观。容器可以包括用于支撑悬挂文件夹的线插件。

9. 发明授权

US5805100A Method and apparatus for universal display of alphanumeric data on radar displays 失效
标题翻译：用于在雷达显示器上通用显示字母数字数据的方法和装置
公开(公告)号：US5805100A
公开(公告)日：1998-09-08
申请号：US732865
申请日：1996-10-15
申请人： Eric Karl Becker , Robert John Olson , Robert Stebbing Doyle
发明人： Eric Karl Becker , Robert John Olson , Robert Stebbing Doyle
IPC分类号： G01S7/06 , G01S7/22 , G01S13/95
CPC分类号： G01S7/064 , G01S7/22 , G01S13/95
摘要： A radar system embeds information into the radar picture data for display on any display device. The radar receiver communicates weather data to a signal processor which generates a weather array. An I/O processor transmits data in the weather array to a display device via a picture bus. Alphanumeric data which is to be embedded into or combined with the weather array is stored in a message array. Font information for each alphanumeric character is stored in a font array. The message array and the font array are combined and translated into a text array which corresponds to the weather array. Prior to transmitting each radial of data to the display device, the I/O processor copies the appropriate radial data from the text array to the weather array thereby causing the desired alphanumeric characters to be displayed on the display device.
摘要翻译：雷达系统将信息嵌入到雷达图像数据中，以便在任何显示设备上显示。雷达接收器将天气数据传送到产生天气阵列的信号处理器。 I / O处理器通过图像总线将天气阵列中的数据发送到显示设备。要嵌入或与天气阵列组合的字母数字数据存储在消息数组中。每个字母数字字符的字体信息存储在字体数组中。消息数组和字体数组被组合并转换为对应于天气阵列的文本数组。在将每个径向数据发送到显示设备之前，I / O处理器将适当的径向数据从文本阵列复制到天气阵列，从而使所需的字母数字字符显示在显示设备上。

10. 发明授权

US1445545A Butter tub 失效
标题翻译：黄油桶
公开(公告)号：US1445545A
公开(公告)日：1923-02-13
申请号：US54545022
申请日：1922-03-21
申请人： JOHN OLSON
发明人： JOHN OLSON
IPC分类号： B65D8/04 , B65D45/02
CPC分类号： B65D45/02

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